Mattress-wetting (nocturnal enuresis) in kids

Is bed-wetting in kids — also called “sleep enuresis” — an indication of sickness? Does it point out a toddler is lazy or defiant? Making an attempt to get consideration? Affected by habits issues?

Wet bed sheets in a child's bed, copyright 2019 Parenting Science

The reply — most often — isn’t any. Children who moist the mattress aren’t lazy. Stress can contribute to enuresis, however most kids who moist the mattress don’t have habits issues. And whereas bed-wetting might be brought on by urinary tract infections and constipation, children with these situations are inclined to expertise incontinence each night time and day. If a toddler’s solely symptom is bed-wetting, illness is an unlikely trigger.

As a substitute, researchers suppose an important causes of bed-wetting are associated to the physiology of nighttime urine management. A toddler’s bladder is perhaps overactive. The kid may produce an excessive amount of urine through the night time. Or the kid may sleep too deeply to awaken when she or he must urinate.

How ought to households reply to bed-wetting? Getting knowledgeable is the most effective first step. Right here’s a information to frequent questions, and an evidence-based information for dealing with enuresis.

At what age ought to we anticipate kids to cease wetting the mattress?

We aren’t born with full bladder management. It takes time to develop. So bed-wetting is a traditional a part of early childhood. When does this variation? 

Research counsel that the majority younger kids cease wetting the mattress between the ages of 4 and 5. However some children could obtain nighttime dryness even earlier. And a hefty share of 5-year-olds — round 20% — should expertise bed-wetting a minimum of as soon as per week (Kawauchi et al 2001; Butler et al 2005; Jansson et al 2005). 

By conference, researchers sometimes outline nocturnal enuresis as wetting the mattress in people who’re a minimum of 5 years previous (Franco et al 2013). However we shouldn’t let this rule of thumb mislead us. It’s common for a 5-year-old to moist the mattress frequently.

How frequent is bed-wetting after the age of 5?

One cheap guess is that roughly 15-20% of children within the early grades of main college — 6- and 7-year olds — nonetheless moist the mattress now and again. As children grow old, the numbers diminish, in order that by puberty the share of people wetting the mattress might be lower than 5%.

But it surely’s vital to know: Research have reported a variety of estimates — from charges below 3% to charges exceeding 24%. And whereas a number of the variation could mirror actual variations between the teams being studied, lots is determined by what researchers rely as bed-wetting.

As an illustration, some research have counted anybody who wets the mattress a minimum of twice per thirty days. Others have counted solely these people who moist the mattress a minimum of twice per week. And as Richard Butler has proven, it makes an enormous distinction.

In a research of greater than 8200 British kids (aged 7.5 years), Butler and his colleagues determined to measure bed-wetting each methods. Whereas simply 2.6% of children moist the mattress a minimum of twice per week, greater than 15% of youngsters moist the mattress a minimum of twice per thirty days (Butler et al 2005).

In one other research, researchers reviewed the medical data of greater than 1100 American kids between the ages of 8 and 11. The researchers counted children as having enuresis if both of those statements had been true:

  • a toddler was wetting the mattress a minimum of twice per week, or
  • a toddler skilled bed-wetting as sometimes as as soon as per thirty days, however together with signs of “clinically vital misery or impairment.”

Utilizing these requirements, the researchers decided that about 4.5% of children had a bed-wetting drawback (Shreeram et al 2009).

So there isn’t anyone statistic that sums all of it up. However nonetheless researchers measure enuresis, it’s clear that bed-wetting isn’t a uncommon or uncommon drawback.

Mattress-wetting has been documented all around the world — in Africa, the Americas, Asia, Australia, Europe, and the Center East (e.g., Fockema et al 2012; Vasconcelos et al 2017; Tai et al 2007; Sureshkumar et al 2009; Butler and Heron 2008; Mohammadi et al 2019). And it persists even amongst adults.

For instance, in surveys carried out in Hong Kong and South Korea, roughly 2.5% of respondents between the ages of 16 and 40 reported have a minimum of occasional signs of nocturnal enuresis (Yeung et al 2004; Baek et al 2013).

What causes bed-wetting?

Researchers acknowledge a lot of doable causes. The most typical embody:

  • decreased bladder capability, and/or an overactive bladder 
  • an excessive amount of urine manufacturing at night time (brought on by a developmental delay in a toddler’s nighttime launch of anti-diuretic hormones)
  • failure to awaken in response to the feeling of a full bladder
  • urinary tract an infection
  • constipation
  • obstructive sleep apnea

However docs will search for totally different causes relying on a affected person’s historical past.

Mattress-wetting in kids who was once dry

Some kids obtain nighttime dryness throughout early childhood, after which develop an issue later. Medical doctors name this secondary nocturnal enuresis (SNE) — bed-wetting in a toddler who was beforehand dry for a minimum of 6 months.

When this type of back-peddling occurs, pediatricians need to be sure the baby doesn’t endure from a brand new medical situation — like a urinary tract an infection or constipation.

Urinary tract infections can create a persistent urge to urinate. Constipation can put stress on the bladder, in order that the bladder’s capability is vastly diminished (Caldwell et al 2005).

Secondary nocturnal enuresis (SNE) has additionally been linked with stress (Caldwell et al 2005), anorexia (Kanbur et al 2010; Kanbur et al 2011), and the onset of sort 1 diabetes (Roche et al 2005).

Mattress-wetting in kids who’ve by no means achieved nighttime dryness

That is referred to as main noctural enuresis (PNE), and it too might be linked with urinary tract infections, constipation, and stress (Robson et al 2005). 

However researchers suppose that the majority instances are precipitated developmental components referring to bladder perform and/or sleep.

As an illustration, relating to bladder perform, there’s proof that some children have bladders that function at decreased capability through the night time (Borg et al 2018).

Different kids could have overactive bladders that leak earlier than they’re full (Nevéus 2019; Mattsson 2019). 

And there’s motive to suppose that some children expertise decrease nighttime ranges of vasopressin, a hormone that tends to suppress the manufacturing of urine. Consequently, their bladders refill quicker —  rising the chance of bed-wetting (Wille 1994; Angeli et al 2023). 

What about sleep? How may sleep patterns have an effect on bed-wetting?

First, there’s a idea about arousal thresholds — how onerous it’s to wake somebody up.

When children don’t get sufficient sleep, their brains usually attempt to compensate by sleeping extra deeply when the chance arises. And deep sleep can improve the chance of bed-wetting. Children aren’t woke up by the sensations of a full bladder (Mattsson et al 2019).

So perhaps some children are wetting the mattress as a result of they endure from an excessive amount of disrupted sleep.

Proof in favor of this rationalization comes from research that monitored kids in a single day utilizing sleep polysomnography. The youngsters with enuresis skilled extra fragmented sleep patterns, they usually gave the impression to be more durable to arouse (Soster et al 2017).

Moreover, one other research — combining physiological measures and parental sleep diaries — reported that kids with nocturnal enuresis tended to expertise extra night time wakings and daytime tiredness (Cohen-Zrubavel et al 2011).

As well as, researchers observed that roughly 50% of youngsters’s night time wakings had been triggered by an episode of bed-wetting. Children both wakened spontaneously after wetting the mattress, or their dad and mom woke them up (Cohen-Zrubavel et al 2011).

It’s doable, then, that bed-wetting — and the best way households reply to bed-wetting — might create a vicious cycle. Children develop into sleep-deprived, which leads them to sleep so deeply that they moist the mattress. Then the bed-wetting episodes set off additional sleep disruptions and sleep deprivation.

There’s additionally motive to suppose that bed-wetting might be brought on by obstructive sleep apnea.

Enuresis is extra frequent in kids who are suffering from respiratory abnormalities, like obstructive sleep apnea (Brown et al 2009; Kovacevic et al 2014; Jönson et al 2017; Wada et al 2018; Bascom et al 2019). And this hyperlink is sensible, as a result of sleep-disordered respiratory is thought to trigger hormonal adjustments that end in larger nighttime urine manufacturing (Umlauf and Chasens 2003). 

So perhaps some kids expertise bed-wetting as a facet impact of their respiratory issues. In help of this concept, researchers report that surgical remedies for extreme sleep apnea are sometimes adopted by enhancements in bed-wetting. Some children cease wetting the mattress after having their adenoids and tonsils eliminated (Jeyakumar et al 2012; Ding et al 2017).

One other chance is that an underlying developmental issue triggers each sleep troubles and bed-wetting.

Researchers report that children with nocturnal enuresis don’t simply awaken extra usually. Additionally they expertise extra stressed limb actions (Dhondt et al 2014; Dhondt et al 2015). So perhaps there’s something awry with the mind techniques that management all of those phenomena — sleep, nighttime muscle actions, and urination (Dhondt et al 2014; Dhondt et al 2015).

Is bed-wetting “psychological” — the symptom of a psychiatric dysfunction?

No. There is proof that children with habits issues usually tend to expertise urinary incontinence. However most kids who moist the mattress don’t have these habits issues.

As an illustration, kids recognized with oppositional defiant dysfunction, or ODD, could also be at greater threat for having bladder management issues, together with nighttime enuresis. However most kids who moist the mattress don’t have any signs of ODD (von Gontard et al 2015).

Equally, children recognized with ADHD (consideration deficit hyperactivity dysfunction) usually tend to endure from nocturnal enuresis (Shreeram et al 2009; Yang et al 2022). But as soon as once more, most children who moist the mattress shouldn’t have ADHD.

So bed-wetting, by itself, just isn’t an indication that your baby suffers from any underlying behavioral or emotional issues. 

That doesn’t imply that psychological components are irrelevant. As famous above, stress could also be a contributing think about some instances of bed-wetting. It’s additionally clear that bed-wetting can trigger misery. Children with continual bed-wetting issues endure usually tend to endure from low shallowness (e.g., Collier et al  2002; Kanaheswari et al 2012; Grzeda et al 2017a).

However the previous concept that bed-wetting is “psychological” has been debunked. Learn extra about it in my Parenting Science article, “Mattress-wetting in scientific perspective.”

Does bed-wetting run in households?

Many years of analysis signifies that nocturnal enuresis has a genetic part (Breinbjerg et al 2023). As an illustration, if in case you have a twin sibling who wets the mattress, your possibilities of sharing this drawback is determined by the diploma of genetic relatedness. Monozygotic twins (who share nearly 100% of their DNA) are practically twice as prone to present concordance as dizygotic twins (who share solely about 50% of their DNA).

As well as, moms who report having to urinate continuously through the night time usually tend to have children who moist the mattress (Montaldo et al 2010). And children usually tend to endure from extreme enuresis if they’ve a number of father or mother with a historical past of bed-wetting (von Gontard et al 2011).

Researchers speculate that sure traits — like the quantity of urine produced at night time, or the tendency to sleep deeply — is perhaps managed by our genes (Schaumburg et al 2008; Wang 2007).

What about bathroom coaching practices? Do they play any function within the improvement of enuresis? 

It’s doable. Specifically, the early use of an method referred to as “elimination communication” (EC) has been linked with decrease charges of bed-wetting.

In a survey of greater than 18,000 dad and mom, researchers in China discovered that kids had been much less prone to expertise nocturnal enuresis if that they had begun elimination communication earlier than the age of 6 months (Wang et al 2019).

Elimination communication calls for that caregivers play shut consideration to their infants’ indicators. When it appears doubtless {that a} child is able to urinate, the caregiver holds the newborn’s naked backside over a rest room and encourages the newborn to void. You possibly can learn extra about this system right here.

Therapies: What are the most effective methods to take care of bed-wetting?

As famous above, it’s vital to deal with any underlying illnesses, infections, and sources of stress. However for most children with main nocturnal enuresis, these steps aren’t prone to remedy the issue. At the moment, the therapies with the most effective proof of their favor are:

  • bed-wetting alarms, and
  • desmopressin, an artificial model of the anti-diuretic hormone, vasopressin.

Mattress-wetting alarms use the identical know-how as diaper alarms. A moisture sensor is connected to the kid’s underpants. When the kid urinates, a sound awakens him. Desmopression, when it prescribed by a doctor, is taken earlier than bedtime, and suppresses urine manufacturing in a single day. How do these therapies evaluate?

Alarms are extra disruptive to make use of, however they appear more practical in the long term.

In research testing the effectiveness of alarms, children slept with mattress wetting alarms each night time for 12 weeks, and roughly half the youngsters stopped wetting the mattress (Glazener et al 2005).

The alarms appeared to work even higher when coaching packages included an “overlearning” part, which suggests giving children further fluids earlier than bedtime in order that they’ve extra alternatives to get up and urinate  (Glazener et al 2005).

Analysis signifies that desmopressin can yield comparable outcomes, with one vital distinction: Children who use alarms usually tend to keep dry after therapy has concluded (Tune et al 2019; Peng et al 2018).

Thus, research favor the usage of alarms — if you possibly can tolerate the fuss. Alarms are extra disruptive, and for that reason, many households that attempt alarms surrender on them.

Are you able to enhance bed-wetting in kids by limiting their caffeine consumption?

Caffiene is a widely known diuretic, and it’s present in meals like cocoa, espresso, and cola. Is is feasible that some children are experiencing bed-wetting as a facet impact of consuming these meals? A latest, managed research means that that is doable.

Researchers recruited greater than 500 bed-wetting individuals (ranging in age between 6 and 15 years), and randomly assigned every particular person to comply with certainly one of two regimens: Every day consumption of 90-110 mg of caffeine, or every day consumption of lower than 30 mg of caffeine. After a month, some children in each teams had stopped wetting the mattress at night time. However this final result was far more frequent among the many children who had consumed much less caffeine (Rezakhaniha et al 2023). The takeaway? In case your baby is at the moment consuming caffeine, this method could also be price a attempt.

What about merely waking your child up at night time to go to the lavatory?

This tactic, referred to as “lifting,” was examined in a randomized experiment on 4- and 5-year-olds, and there was a discount in nocturnal enuresis signs after six months (van Dommelen et al 2009). 

However extra not too long ago, researchers reported much less encouraging information. In a research monitoring greater than 1250 bed-wetting kids from the age of seven.5 years, lifting was not linked with long-term enhancements. Quite the opposite, children subjected to lifting had been extra prone to be wetting the mattress two years later (Grzeda et al 2017b).

Lifting could also be problematic as a result of dad and mom can’t know for certain when a sleeping baby must urinate. Consequently, children could also be woke up when their bladders aren’t full — making it more durable for youngsters to study to affiliate the sensations of a full bladder with a nighttime lavatory go to.

We’d like extra analysis to make certain. In the meantime, the obtainable proof means that lifting is much less efficient than alarms (Caldwell et al 2013), and probably counterproductive.

Do punishments work?

Children affected by nocturnal enuresis don’t moist the mattress on function. It’s unfair responsible or punish them for mattress wetting. And it seems to make issues worse.

As famous above, children who moist the mattress could battle with emotions of embarrassment, disgrace, or poor self-image about their situation (Collier et al  2002; Kanaheswari et al 2012; Grzeda et al 2017). And these emotional stresses might make it more durable for youngsters to develop bladder management (Glazier et al 2005). So the very last thing you need to do is actively punish children. It’s including gasoline to the hearth.

For instance, in a research carried out in Egypt, parental punishment for bed-wetting was linked with extra frequent nighttime accidents, and youngsters who had been punished skilled extra extreme psychological misery (Al-Zaben et al 2015).

Equally, in a British research, dad and mom who expressed displeasure in response to early mattress wetting episodes had been extra prone to have children who nonetheless moist the mattress at age 7 ½ (Butler 2005). And in research carried out in Italy and the Netherlands, children had been much less doubtless to enhance if their dad and mom punished them for nighttime accidents (Ferrara et al 2016; van der Wal et al 1996). 

Ought to dad and mom attempt to inspire children with rewards?

To this point, there’s little proof that rewards are efficient (Glazener et al 2005; van Dommelen et al 2009). Actually, in a single research, researchers discovered that providing rewards to 7.5-year-olds really elevated the chance of bed-wetting two years later (Grzeda et al 2017b).

So I’m skeptical, and anxious in regards to the message it’d ship. When dad and mom provide rewards to children for staying dry at night time, the implication is that bed-wetting is below aware management, however it’s not. Children moist the mattress whereas they’re asleep. And I’d wager that the majority children need us to know. They’re already motivated. They don’t want bribes. If they might wake themselves up, they’d do it.

Extra details about the myths of bed-wetting

For extra details about nocturnal enuresis, try the article, Mattress-wetting in scientific perspective: Damaging myths and misconceptions.

References: Enuresis in kids

Abramovitch IB, and Abramovitch HH. 1989. Enuresis in cross-cultural perspective: a comparability of coaching for elimination management in three Israeli ethnic teams. J Soc Psychol. 129(1):47-56.

Al-Zaben FN and Sehlo MG. 2015. Punishment for bedwetting is related to baby despair and decreased high quality of life. Baby Abuse Negl. 43:22-9.

Angeli M, Bitsori M, Rouva G, Galanakis E. 2023. The function of the autonomic nervous system in nocturnal enuresis. J Pediatr Urol. 19(1):6-18.

Baek M, Park Okay, Lee HE, Kang JH, Suh HJ, Kim JH, Lee SD, Pai KS, Han SW, Park YH, Kim KD; Korean Youngsters’s Continence and Enuresis Society. 2013. A nationwide epidemiological research of nocturnal enuresis in Korean adolescents and adults: inhabitants based mostly cross sectional research. J Korean Med Sci. 28(7):1065-70.

Bascom A, McMaster MA, Alexander RT, MacLean JE. 2019. Nocturnal enuresis in kids is related to variations in autonomic management. Sleep. 42(3). pii: zsy239

Borg B, Kamperis Okay, Olsen LH, Rittig S. 2018. Proof of decreased bladder capability throughout nighttime in kids with monosymptomatic nocturnal enuresis. J Pediatr Urol. 14(2):160.e1-160.e6.

Breinbjerg A, Jørgensen CS, Borg B, Rittig S, Kamperis Okay, Christensen JH. 2023. The genetics of incontinence: A scoping evaluation. Clin Genet. 104(1):22-62.

Butler RJ, Golding J, Heron J; ALSPAC Research Staff. 2005. Nocturnal enuresis: a survey of parental coping methods at 7 1/2 years. Baby Care Well being Dev. 31(6):659-67.

Butler RJ and Heron J. 2008. The prevalence of rare bedwetting and nocturnal enuresis in childhood. A big British cohort. Scand J Urol Nephrol. 42(3):257-64.

Caldwell PH, Nankivell G, Sureshkumar P. 2013. Simple behavioural interventions for nocturnal enuresis in children. Cochrane Database Syst Rev. (7):CD003637.

Caldwell PH, Edgar D, Hodson E, Craig JC. 2005. 4. Bedwetting and toileting issues in kids. Med J Aust. 182(4):190-5.

Cohen-Zrubavel V, Kushnir B, Kushnir J, Sadeh A. 2011. Sleep and sleepiness in kids with nocturnal enuresis. Sleep. 34(2):191-4.

Collier J, Butler RJ, Redsell SA, and Evans JH. 2002. An investigation of the affect of nocturnal enuresis on kids’s self-concept. Scand J Urol Nephrol. 36(3):204-8.

Dhondt Okay, Baert E, Van Herzeele C, Raes A, Groen LA, Hoebeke P, Vande Walle J. 2014. Sleep fragmentation and elevated periodic limb actions are extra frequent in kids with nocturnal enuresis. Acta Paediatr. 103(6):e268-72.

Dhondt Okay, Van Herzeele C, Roels SP, Raes A, Groen LA, Hoebeke P, Walle JV. 2015. Sleep fragmentation and periodic limb actions in kids with monosymptomatic nocturnal enuresis and polyuria. Pediatr Nephrol. 2015 Jul;30(7):1157-62.

Ding H, Wang M, Hu Okay, Kang J, Tang S, Lu W, Xu L. 2017. Adenotonsillectomy can lower enuresis and sympathetic nervous exercise in kids with obstructive sleep apnea syndrome. J Pediatr Urol. 13(1):41.e1-41.e8.

Erdem E, Lin A, Kogan BA, Feustel PJ. 2006. Affiliation of elimination dysfunction and physique mass index. J Pediatr Urol. 2(4):364-7.

Ferrara P, Dell’Aquila L, Perrone G, Spina G, Miconi F, Rapaccini V, Del Vescovo E, Di Lazzaro V, Verrotti A. 2016. A Doable Pathogenic Linkage Amongst Headache, Migraine, and Nocturnal Enuresis in Youngsters. Int Neurourol J. 20(4):311-315

Fockema MW, Sweet GP, Kruger D, and Haffejee M. 2012. Enuresis in South African kids: prevalence, related components and parental notion of therapy. BJU Int.110(11 Pt C):E1114-20.

Franco I, von Gontard A, De Gennaro M. 2013. Worldwide Youngsters’s Continence Society. Analysis and therapy of nonmonosymptomatic nocturnal enuresis: a standardization doc from the Worldwide Youngsters’s Continence Society. J Pediatr Urol 9:234-43.

Glazener CM, Evans JH, Peto RE. 2005. Alarm interventions for nocturnal enuresis in children. Cochrane Database Syst Rev. 18;(2):CD002911.

Grzeda MT, Heron J, von Gontard A, Joinson C. 2017a. Results of urinary incontinence on psychosocial outcomes in adolescence. Eur Baby Adolesc Psychiatry. 26(6):649-658.

Grzeda MT, Heron J, Tilling Okay, Wright A, Joinson C. 2017b. Inspecting the effectiveness of parental methods to beat bedwetting: an observational cohort research. BMJ Open. 7(7):e016749.

Gümüş B, Vurgun N, Lekili M, Işcan A, Müezzinoğlu T, and Büyuksu C. 1999. Prevalence of nocturnal enuresis and accompanying components in kids aged 7-11 years in Turkey.Acta Paediatr. 1999 Dec;88(12):1369-72.

Hashem M, Morteza A, Mohammad Okay, and Ahmad-Ali N. 2013. Prevalence of nocturnal enuresis in class aged kids: the function of private and fogeys associated socio-economic and academic components. Iran J Pediatr. 23(1):59-64.

Jansson UB, Hanson M, Sillén U, Hellström AL. 2005. Voiding sample and acquisition of bladder management from delivery to age 6 years–a longitudinal research. J Urol. 174(1):289-93.

Jeyakumar A, Rahman SI, Armbrecht ES, Mitchell R. 2012. The affiliation between sleep-disordered respiratory and enuresis in kids. Laryngoscope. 122(8):1873-7.

Joinson C, Grzeda MT, von Gontard A, Heron J. 2019. A potential cohort research of biopsychosocial components related to childhood urinary incontinence. Eur Baby Adolesc Psychiatry. 28(1):123-130.

Joinson C, Sullivan S, von Gontard A, Heron J. 2016. Early childhood psychological components and threat for bedwetting at college age in a UK cohort. Eur Baby Adolesc Psychiatry. 25(5):519-28.

Joinson C, Sullivan S, von Gontard A, Heron J. 2016. Traumatic Occasions in Early Childhood and Developmental Trajectories of Bedwetting at College Age. J Pediatr Psychol. 41(9):1002-10.

Jönson Ring I, Markström A, Bazargani F, Nevéus T. 2017. Sleep disordered inhaling enuretic kids and controls. J Pediatr Urol. 13(6):620.e1-620.e6.

Kanbur N, Pinhas L, Lorenzo A, Farhat W, Licht C, and Katzman DK. 2010. Nocturnal enuresis in adolescents with anorexia nervosa: Prevalence, potential causes, and pathophysiology. Int J Eat Disord.

Kanbur N, Pinhas L, Lorenzo A, Farhat W, Licht C, Katzman DK.2011. Nocturnal enuresis in adolescents with anorexia nervosa: prevalence, potential causes, and pathophysiology. Int J Eat Disord. 44(4):349-55.

Kanaheswari Y, Poulsaeman V and Chandran V. 2012. Shallowness in 6- to 16-year-olds with monosymptomatic nocturnal enuresis. J Paediatr Baby Well being. 48(10):E178-82.

Kawauchi A, Tanaka Y, Yamao Y, Inaba M, Kanazawa M, Ukimura O, Mizutani Y and Miki T. 2001. Comply with-up research of bedwetting from 3 to five years of age. Urology. 58(5):772–776.

Kovacevic L, Wolfe-Christensen C, Lu H, Toton M, Mirkovic J, Thottam PJ, Abdulhamid I, Madgy D2, Lakshmanan Y. 2014. Why does adenotonsillectomy not appropriate enuresis in all kids with sleep disordered respiratory? J Urol 191(5 Suppl):1592-6.

Lin J, Rodrigues Masruha M, Prieto Peres MF, Cianciarullo Minett TS, de Souza Vitalle MS, Amado Scerni D, and Pereira Vilanova LC. 2012. Nocturnal enuresis antecedent is frequent in adolescents with migraine. Eur Neurol. 2012;67(6):354-9.

Longstaffe S, Moffatt ME, and Whalen JC. 2000. Behavioral and self-concept adjustments after six months of enuresis therapy: a randomized, managed trial. Pediatrics. 105(4 Pt 2):935-40.

Mattsson S, Persson D, Glad Mattsson G, Lindström S. 2019. Evening-time diuresis sample in kids with and with out main monosymptomatic nocturnal enuresis. J Pediatr Urol. 15(3):229.e1-229.e8

Mohammadi M, VaisiRaiegani AA, Jalali R, Ghobadi A, Salari N. 2019. The Prevalence of Nocturnal Enuresis amongst Iranian Youngsters: A Systematic Evaluate and Meta-Evaluation. Urol J. 2019 Aug 17. doi: 10.22037/uj.v0i0.5194.

Montaldo P, Tafuro L, Narciso V, Apicella A, Iervolino LR, Del Gado R. 2010. Correlations between enuresis in kids and nocturia in moms. Scand J Urol Nephrol. 44(2):101-5.

Nationwide Medical Guideline Centre (UK). 2010. Nocturnal Enuresis: The Administration of Bedwetting in Youngsters and Younger Individuals. NICE Medical Pointers, No. 111. London: Royal School of Physicians (UK).

Nevéus T. 2019. The quantity of urine voided in mattress by kids with enuresis. J Pediatr Urol. 15(1):31.e1-31.e5.

Pashapour N, Golmahammadlou S, and Mahmoodzadeh H. 2008. Nocturnal enuresis and its therapy amongst primary-school kids in Oromieh, Islamic Republic of Iran. East Mediterr Well being J. 14(2):376-80.

Peng CC, Yang SS, Austin PF, Chang SJ. 2018. Systematic Evaluate and Meta-analysis of Alarm versus Desmopressin Remedy for Pediatric Monosymptomatic Enuresis. Sci Rep. 8(1):16755.

Rezakhaniha S, Rezakhaniha B, Siroosbakht S. 2023. Restricted caffeine consumption as first-line therapy in managing main monosymptomatic enuresis in kids: how efficient is it? A randomised scientific trial. BMJ Paediatr Open. 7(1):e001899.

Roche EF, Menon A, Gill D, Hoey H. 2005. Medical presentation of sort 1 diabetes. Pediatr Diabetes. 6(2):75-8.

Schaumburg HL, Kapilin U, Blåsvaer C, Eiberg H, von Gontard A, Djurhuus JC, and Rittig S. 2008. Hereditary phenotypes in nocturnal enuresis. BJU Int.102(7):816-21.

Shreeram S, He JP, Kalaydjian A, Brothers S, and Merikangas KR. 2009. Prevalence of enuresis and its affiliation with attention-deficit/hyperactivity dysfunction amongst U.S. kids: outcomes from a nationally consultant research. J Am Acad Baby Adolesc Psychiatry. 48(1):35-41.

Tune P, Huang C, Wang Y, Wang Q, Zhu W, Yue Y, Wang W, Feng J, He X, Cui L, Wan T, Wen J. 2019. Comparability of desmopressin, alarm, desmopressin plus alarm, and desmopressin plus anticholinergic brokers within the administration of paediatric monosymptomatic nocturnal enuresis: a community meta-analysis. BJU Int. 123(3):388-400.

Soster LA, Alves RC, Fagundes SN, Lebl A, Garzon E, Koch VH, Ferri R, Bruni O. 2017. Non-REM Sleep Instability in Youngsters With Major Monosymptomatic Sleep Enuresis. J Clin Sleep Med. 13(10):1163-1170

Spee-van der Wekke J, Hirasing RA, Meulmeester JF, Radder JJ. 1998. Childhood nocturnal enuresis in The Netherlands. Urology. 51(6):1022-6.

Sullivan S, Joinson C, Heron J. 2015. Elements Predicting Atypical Improvement of Nighttime Bladder Management. J Dev Behav Pediatr. 36(9):724-33

Sureshkumar P, Jones M, Caldwell PH, Craig JC. 2009. Threat components for nocturnal enuresis in school-age kids. J Urol. 182(6):2893-9.

Tai HL, Chang YJ, Chang SC, Chen GD, Chang CP, Chou MC. 2007. The epidemiology and components related to nocturnal enuresis and its severity in main college kids in Taiwan. Acta Paediatr. 96(2):242-5.

Umlauf MG and Chasens ER. 2003. Sleep disordered respiratory and nocturnal polyuria: nocturia and enuresis. Sleep Med Rev. 7(5):403-11.

Wang QW, Wen JG, Zhang RL, Yang HY, Su J, Liu Okay, Zhu QH, Zhang P. 2007. Household and segregation research: 411 Chinese language kids with main nocturnal enuresis. Pediatr Int. 49(5):618-22.

Wille S, Anveden I. 1995. Social and behavioural views in enuretics, former enuretics and non-enuretic controls. Acta Paediatr. 84(1):37-40.

Vasconcelos MMA, East P, Blanco E, Lukacz ES, Caballero G, Lozoff B, Gahagan S. 2017. Early Behavioral Dangers of Childhood and Adolescent Daytime Urinary Incontinence and Nocturnal Enuresis. J Dev Behav Pediatr. 38(9):736-742.

von Gontard A, Heron J, Joinson C. 2011. Household historical past of nocturnal enuresis and urinary incontinence: outcomes from a big epidemiological research. J Urol. 185(6):2303-6.

von Gontard A, Niemczyk J, Thomé-Granz S, Nowack J, Moritz AM, Equit M. 2015. Incontinence and parent-reported oppositional defiant dysfunction signs in younger kids–a population-based research. Pediatr Nephrol. 30(7):1147-55.

Wada H, Kimura M, Tajima T, Shirahama R, Suzuki Y, Suzuki Y, Hayashi T, Maruyama Okay, Endo M, Sakamoto N, Ikeda A, Gozal D, Tanigawa T. 2018. Nocturnal enuresis and sleep disordered inhaling main college kids: Potential implications. Pediatr Pulmonol. 53(11):1541-1548.

Wang QW, Wen JG, Zhang RL, Yang HY, Su J, Liu Okay, Zhu QH, Zhang P. 2007. Household and segregation research: 411 Chinese language kids with main nocturnal enuresis. Pediatr Int. 49(5):618-22.

Wang XZ, Wen YB, Shang XP, Wang YH, Li YW, Li TF, Li SL, Yang J, Liu YJ, Lou XP, Zhou W, Li X, Zhang JJ, Tune CP, Jorgensen CS, Rittig S, Bauer S, Mosiello G, Wang QW, Wen JG. 2019. The affect of delay elimination communication on the prevalence of main nocturnal enuresis-a survey from Mainland China. Neurourol Urodyn. 38(5):1423-1429.

Yang TK, Huang WY, Guo YJ, Chen YF, Chang HC, Huang KH. 2022. Prevalence of Decrease Urinary Tract Signs in Youngsters with Consideration-Deficit/Hyperactivity Dysfunction: Comparability of Hospital and Inhabitants-Based mostly Cohorts of 13,000 Sufferers. J Clin Med. 11(21):6393.

Yeung CK, Sihoe JD, Sit FK, Bower W, Sreedhar B, Lau J. 2004. Traits of main nocturnal enuresis in adults: an epidemiological research. BJU Int. 93(3):341-5.

Zhang A, Li S, Zhang Y, Jiang F, Jin X, Ma J. 2019. Nocturnal enuresis in overweight kids: a nation-wide epidemiological research from China. Sci Rep. 9(1):8414.

Content material of “Mattress-wetting (sleep enuresis) in kids” final modified 9/2023

Parts of this textual content appeared in a earlier Parenting Science article, “Mattress-wetting in kids” (2010), posted on the identical URL, in addition to in a model printed in 2019.

Picture of moist bedsheets and toy owl copyright 2019 Parenting Science

Content material final modified 8/2023